Two abstracts based upon machine perfusion with Lifeport were presented at the International Transplant Congress (ITC) meeting in Vancouver.
Plata-Munoz et al presented their findings from a study to evaluate the impact of machine perfusion on graft function in DCD kidneys, graded using the deceased donor scoring (DDS) system. The results showed that compared with cold storage, machine perfusion reduced the incidence of DGF in all DDS grades and improved graft function of optimal (grade A) and borderline (grade B) DCD kidneys. While the results did not show improved graft function in marginal (grade C) kidneys, machine perfusion did allow the evaluation and use of some of these high risk kidneys, which may previously have been discarded outright.
Plata-Munoz et al. Beneficial Effect of Preservation by Machine Perfusion on Postoperative Outcome Of Kidneys From Controlled Donors After Cardiac Death. Presented at International Transplant Congress, Vancouver 2010.
Yushkov et al presented a retrospective analysis of 470 preselected kidneys for transplantation, to evaluate whether the machine measured renal resistance (MMRR) on the LifePort was predictive of 1-year renal allograft survival. Their results show that of the renal and donor parameters assessed, MMRR at 3 hours was the earliest significant predictor of 1-year allograft outcome.
Yushkov YY et al. Machine Measured Renal Resistance (MMRR) is the most sensitive tool for prediction of early renal allograft survival. Presented at International Transplant Congress, Vancouver 2010.