Machine perfusion of expanded criteria donor (ECD) kidneys

10 January 2014  //  Clinical Evidence

The effects of machine perfusion (MP) versus static cold storage (SCS) on delayed graft function (DGF) and early graft survival in expanded criteria donor (ECD) kidneys was examined in a prospective, randomized international clinical study. A total of 91 consecutive ECD after brain death (as defined according to the United Network of Organ Sharing definition) were included in the trial. From each donor, one kidney was randomized to MP and the contralateral kidney to SCS.

Key results

Results found 1-year graft survival was significantly higher in MP ECD kidneys compared with SCS kidneys (92.3% vs. 80.2%, p=0.02). Furthermore, DGF occurred in 27 patients in the SCS group (29.7%) and in 20 patients in the MP group (22%). A logistic regression model found MP significantly reduced the risk of DGF (OR 0.460, p=0.047). The incidence of non-function in the SCS group (12%) was four times higher than in the MP group (3%) (p=0.04).

Reference

Treckmann J., et al. Transpl Int. 2011;24(6):548–54.