O:PAIRS is a worldwide initiative to establish a strong base of clinical evidence on the ex vivo preservation of kidneys for transplantation. Sponsored by Organ Recovery Systems and led by eminent physician-scientists, O:PAIRS comprises three independent landmark outcomes trials. Each follows a naturalistic study design, separating pairs at recovery to compare patient outcomes from machine-perfused versus static-stored kidneys. Each targets immediate and delayed graft function as primary endpoints and longer-term graft function and survival as secondary endpoints. Each will deliver the rigor possible only in a large, prospective, randomized, controlled, powered clinical trial. And each exclusively features the award-winning, easy-to-use LifePort Kidney Transporter.


Belgium, The Netherlands, Germany
The Machine Preservation Trial stands foremost in the O:PAIRS group: the first large, international, multicenter clinical trial to investigate the relative efficacy and cost-effectiveness of machine versus static preservation. The trial is being conducted in Germany, The Netherlands, and Belgium in collaboration with Eurotransplant and the Deutsche Stiftung Organtransplantation. Start 1 November 2005. End 1 November 2006. Coordinating PI: Rutger Ploeg. N=600 recipients.

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