Protection of the endothelium is proposed to be one of the key mechanisms responsible for the demonstrated benefits of machine perfusion in reducing the incidence of DGF and improving graft survival.1 As shown in Transplantation, the expression of endothelial protective genes is flow-dependent, with interruption of flow during static cold storage disrupting endothelial vasoprotection and leading to apoptosis.1 The LifePort Kidney Transporter uses gentle, pulsatile pressure waves to circulate cold preservation solution through the vasculature of the kidney, thus limiting the risk of endothelial damage during preservation, protecting the viability of the donor kidney, and resulting in a reduced risk of DGF and improved 1-year graft survival.2
1. Gracia-Sancho J, et al. Flow cessation triggers endothelial dysfunction during organ cold storage conditions: strategies for pharmacologic intervention. Transplantation 2010;90:142–49.
2. Moers C, et al. Machine perfusion or cold storage in deceased-donor kidney transplantation. N Engl J Med 2009;360:7–19.