In this clinical study, use of hypothermic machine perfusion (HMP) was investigated in donor livers that had initially been rejected by the originating United Network for Organ Sharing (UNOS) region. Investigators reviewed two groups of patients receiving an isolated primary liver transplantation. A total of 31 patients in the intervention arm received HMP livers and 30 patients in the control arm received static cold-stored (SCS) livers that were matched for donor age, recipient age, cold ischemic time, donor risk index and model end-stage liver disease (MELD) score.
During the 12-month post-transplantation follow-up, compared to SCS, the HMP group showed significantly:
The authors concluded that HMP assists in the safe use of ECD livers, even those rejected by multiple centers. They proposed that this technique will be effective in reducing the incidence of preservation injury in the most susceptible livers, and that its incorporation into clinical practice will help close the gap between organ supply and demand, improving both clinical and economic outcomes of liver transplantation.
Guarrera JV, et al. Am J Transplant. 2015;15(1):161–169.