Kidney Transplantation Using High-Vascular-Resistant Renal Allografts From a Donor Who Had Calcineurin-Induced Functional Acute Kidney Injury

Clinical Evidence

Kidney Transplantation Using High-Vascular-Resistant Renal Allografts From a Donor Who Had Calcineurin-Induced Functional Acute Kidney Injury

Kidney Transplantation Using High-Vascular-Resistant Renal Allografts From a Donor Who Had Calcineurin-Induced Functional Acute Kidney Injury

A case report published by LifeShare Oklahoma showcased two LifePort Kidney Transporter-perfused kidneys that were successfully transplanted, even with high vascular resistance.

The donor was a 34 year old DCD with tacrolimus-induced functional Acute Kidney Injury (AKI) and the following characteristics:

  • High renal resistance (terminal RR 0.83 & 0.70 mmHg/mL/min)
  • Low perfusion flow
  • CIT > 40 hours

Despite these challenges, both kidneys were preserved on LifePort Kidney Transporter for 29 hours and transplanted with excellent outcomes – no post-discharge dialysis, no acute rejection episodes during the one-year follow-up, and stable creatinine levels at one-year follow-up.

The authors concluded that kidney allografts with high renal resistance during HMP, from donors with CNI drug-induced functional AKI, can be successfully used for transplantation.

Read the full article here: https://pubmed.ncbi.nlm.nih.gov/40975673/

Tagged In:

CIT, DCD, Kidney, Renal Resistance