LifePort Liver Transporter

Transforming Preservation in Liver Transplantation

Contact Us about Liver Preservation

Transforming Preservation in Liver Transplantation

LifePort Liver Transporter design, engineering, and performance capabilities are based upon the LifePort prototype system used in the Columbia University Medical Center / New York Presbyterian Hospital and the proven technology platform of the market leading LifePort Kidney Transporter.

LifePort Liver Transporter is in the process of securing US and European regulatory registrations, and is not yet approved for clinical use.

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The Clinical Need in Liver Transplantation

Approximately 2,500 patients in the United States die every year on the liver transplant waiting list before a donor liver becomes available.1 Increasing the number of organs available for transplantation, while reducing post-transplantation complications and shortening the length of hospital stay, are important clinical goals to improve patient outcomes.

1. OPTN/SRTR 2011 Annual Data Report: liver. Accessed June 2014.

Transforming Outcomes

A controlled clinical feasibility study at Columbia University Medical Center/New York Presbyterian Hospital using a prototype LifePort Liver Transporter system found 50 percent fewer patients had biliary complications with LifePort-perfused livers. Early allograft dysfunction was seen in 25 percent of static cold stored livers compared with 5 percent of LifePort-perfused livers (p = 0.08).2 Additionally, patients receiving LifePort perfused livers had a significantly lower length of hospital stay than patients with static cold stored livers (10.9 ± 4.7 days vs. 15.3 ± 4.9 days; p = 0.006).

A second controlled study investigated hypothermic machine preservation versus static cold storage of expanded criteria livers rejected by the originating UNOS region.3 During 12-months post transplantation there were significantly fewer biliary complications in the perfused group (4 vs. 13, respectively; p = 0.016), and early allograft dysfunction rates were also lower (19% vs. 30%). Mean hospital stay was also significantly shorter in the perfused group (13.6 vs. 21.1 days). The results suggest that hypothermic machine perfusion (HMP) of livers is safe and allows for transplantation of expanded criteria livers deemed untransplantable by multiple centers. Study investigators concluded that HMP has the potential to increase the donor pool and the availability of livers for patients on the waiting list.

Full Summary of the Clinical Experience for LifePort Liver Transporter

2. Guarrera JV, et al. Am J Transpl 2010;10:372–81.
3. Guarrera JV, et al. Am J Transpl 2015;15(1):161–9

US Clinical Trial

PILOT (Perfusion to Improve Liver Outcomes in Transplantation) is a prospective randomized multi-
center oxygenated hypothermic machine perfusion study using the LifePort Liver Transporter (LLT)
system with Vasosol® as compared to static cold storage in orthotopic liver transplantation.

This trial is registered with clinical (NCT number 03484455) and has been approved by US
Food and Drug Administration (Investigational Device Exemption) and the Center for Medicare and
Medicaid Services (CMS).

Key Features of the LifePort Liver Transporter

Dual Perfusion

LifePort Liver Transporter is designed to deliver precision-controlled perfusion of the hepatic artery and portal vein.

Programmable Display

The interface displays key data that track real-time organ perfusion status, organ ID number and blood type, cross-clamp and total infusion time, perfusate temperature, hepatic and portal flow, pressure, and total flow.

Trusted Technology

Hypothermic perfusion is supported by redundant preservation systems for safety – dynamic perfusion plus static cold storage. LifePort medical technology has been used by transplant surgeons in more than 120,000 clinical procedures worldwide.

“In our study, the HMP group had significantly less biliary complications than the SCS group, including a lowered number of bile leaks and a significantly lowered number of strictures. Our findings of less biliary complications may be attributed to the better flushing and continuous circulation of adequate oxygen, adenine triphosphate (ATP) substrates and vasodilators to the peribiliary vascular microcirculation.”

Guarrera JV, et al. American Journal of Transplantation. 2015.