A Comprehensive Analysis on the Impact of Hypothermic Machine Perfusion and its Influence on Delayed Graft Function

Clinical Evidence

A Comprehensive Analysis on the Impact of Hypothermic Machine Perfusion and its Influence on Delayed Graft Function

A Comprehensive Analysis on the Impact of Hypothermic Machine Perfusion and its Influence on Delayed Graft Function

This retrospective SRTR data review (2014-2024) from Mayo Clinic published in Transplantation Direct examined the impact of Hypothermic Machine Preservation (HMP) vs Static Cold Storage (SCS) on Delayed Graft Function (DGF). A total of 59,869 kidneys were included in the overall analysis: 31,818 (53.2%) were preserved using HMP, and 28,041 (46.8%) were preserved using SCS.. There were 2,208 matched recipient pairs included in the paired kidney analysis. In each pair, one kidney was preserved using SCS and the other was preserved using HMP.

Overall:

    • Univariate analysis showed increased DGF in HMP group, however the multivariate analysis (taking into account donor and recipient characteristics) showed a statistically significant reduced odds of DGF (adjusted OR, 0.71; 95% CI, 0.66-0.78, P < 0.001)

In the paired kidney population:

  • HMP had significantly lower DGF rate (29.8% vs 36.1%, P < 0.001)
  • No difference in 1 year creatinine, 1 year graft survival, or hospital LOS
  • Marked difference in acute rejection favoring HMP, not significant

In conclusion, HMP significantly lowered the risk of DGF by 29% in the overall population and by 32% in a paired cohort analysis.

Read the full article here: https://journals.lww.com/transplantationdirect/fulltext/2025/12000/a_comprehensive_analysis_on_the_impact_of.4.aspx

Tagged In:

DGF, Kidney