The Clinical Need in Renal Transplantation

Long-term survival of kidney grafts is not improving despite better donor management and improved immunosuppression.1

The number of people needing dialysis for end-stage renal failure is likely to double in the next 10 years.2

Finding a way to bridge the gap between demand and supply of organs is vital.

1-and-3-year graft survival for all deceased donor kidneys is better with LifePort Kidney Transporter compared with static cold storage

Transforming Outcomes with LifePort

With its innovative technology, LifePort Kidney Transporter has revolutionized kidney preservation. Compelling evidence shows that LifePort Kidney Transporter can improve the odds of a good outcome.

Both 1-year and 3-year graft survival for all deceased donor kidneys (DCD) is better with LifePort Kidney Transporter when compared with cold static storage.3,4

Clinical Challenges in Kidney Transplantation

Graft survival in kidney transplantation is strongly impacted by the occurrence of DGF, particularly in kidneys from marginal donors.

Delayed Graft Function (DGF): the clinical challenge

Graft survival in kidney transplantation is strongly impacted by the occurrence of DGF, particularly in kidneys from marginal donors.5,6

Impact of Delayed Graft Function

  • Negative impact on long-term graft  survival6-8
  • Increased risk of acute rejection6
  • Increased healthcare costs6
  • Poor outcomes for the patient6

Transforming outcomes, transforming lives

LifePort Kidney Transporter helps surgeons to transplant kidneys with confidence, even those from marginal donors. State-of-the-art preservation with LifePort has proven to significantly reduce the risk of DGF for all kidney donor types compared with cold static storage.5,6

Routinely protecting and preserving expanded criteria donor (ECD) kidneys and DCD kidneys with LifePort Kidney Transporter could make all the difference.6

LifePort display panel captures detailed performance data in real time

Transforming knowledge: improving decision making

The fully portable LifePort Kidney Transporter captures and displays key performance data in real time.


Onboard digital readouts show pressure, flow rate, renal resistance and temperature of the kidney.

Custom-Made for Kidney Perfusion

The self-contained Perfusion Circuit cradles the organ in cold physiologic solution. A custom-made disposable cannula, situated comfortably on an adjustable mount, swiftly connects LifePort Kidney Transporter to even the most challenging anatomies. And the entire disposable apparatus – complete with Organ Cassette, pressure sensor and preservation solution – loads and unloads in one easy motion.

Clinical Evidence Supports the Use of LifePort Kidney Transporter

The Machine Preservation Trial (MPT), an international prospective randomized controlled clinical trial to investigate the incidence and risk of delayed graft function (DGF) in kidneys preserved by machine perfusion prior to transplantation, demonstrated that machine perfusion with LifePort Kidney Transporter significantly reduces the impact of DGF in all types of DCD kidneys.3–6

Full Summary of the Clinical Evidence for LifePort Kidney Transporter ›

LifePort machine perfusion reduces the impact of DGF
References
1. OPTN & SRTR Annual Data Report 2011, Kidney. Available at:
http://srtr.transplant.hrsa.gov/annual_reports/2011/pdf/2011_SRTR_ADR.pdf (PDF Accessed 29/11/2013).
2. Collins AJ, et al. Clin J Am Soc Nephrol 2009;4(Supplement 1):S5-S11.
3. Moers C., et al. N Engl J Med 2009;360(1):7–19.
4. Moers C., et al. N Engl J Med 2012;366(8):770–1.
5. Treckmann J., et al. Transplant Int 2011;24(6):548–54.
6. Jochmans I., et al. Ann Surg 2010;252(5):756–64.

 

LifePort Kidney Transporter IFU

We received a kidney which had been turned down for transplant elsewhere. The donor had an extensive abdominal aortic dissection which prevented the use of an aortic cuff. The non-invasive nature of the Universal SealRing cannula enabled us to machine perfuse this kidney which would otherwise have been discarded.