Renal Resistance on Hypothermic Machine Perfusion and Acceptance of Deceased Donor Kidney Allografts

Clinical Evidence

Renal Resistance on Hypothermic Machine Perfusion and Acceptance of Deceased Donor Kidney Allografts

Renal Resistance on Hypothermic Machine Perfusion and Acceptance of Deceased Donor Kidney Allografts

A recent study was published in JASN by Nakayama et al. examining how terminal renal resistance in HMP impacts long-term outcomes and utilization of deceased donor kidneys. By analyzing OPTN data from over 36,000 kidney HMP cases, the investigators found:

  • Terminal renal resistance was clinically meaningful for high-KDPI kidneys
  • Low and mid KDPI kidneys should not be discarded solely due to terminal renal resistance
  • If low and mid KDPI kidneys were not discarded solely based on terminal renal resistance, the US could have performed an additional 357 transplants per year

To conclude, terminal renal resistance is a useful supportive metric, but should be applied in a nuanced way alongside KDPI and recipient factors to help increase utilization.

Read the full article here: https://journals.lww.com/jasn/abstract/9900/renal_resistance_on_hypothermic_machine_perfusion.865.aspx

Tagged In:

HMP, KDPI, Kidney