Detailed summaries of key clinical papers on organ transplantation, machine preservation and factors affecting post-transplant outcomes, plus video presentations by leading experts in the field on their clinical experience with machine preservation.
In a first of its kind study, the long-term outcomes of paired kidneys maintained with static cold storage (SCS) versus hypothermic machine perfusion (HMP) following transplantation were investigated. A total of 202 patients were included in the study. Read More ›
A retrospective analysis was performed in 93 patients who had received expanded criteria donor (ECD) kidneys over a 4-year period from July 2007 to July 2009. These ECD kidneys were stored via hypothermic machine perfusion (HMP) using a LifePort® Kidney Transporter and were compared with an age-matched group who received ECD kidneys between 2003 and 2007, stored using static cold storage (SCS). Read More ›
The association between biliary complications and perioperative clinical outcomes and costs were examined in a cross-sectional analysis of national data involving 7,967 patients transplanted between 2011 and 2012. Biliary complications post liver transplantation have been shown to cause prolonged hospital stays, long-term complications, inferior quality of life, increased costs, and potentially exacerbate the donor organ shortage. Read More ›
Despite the increased use of HTK (histidine-tryptophan-ketoglutarate) in liver transplantation over the past decade (currently used in ~30% of liver transplants in Europe and the US), clinical data continue to demonstrate the advantages of UW (University of Wisconsin) solution over HTK. Read More ›
In this clinical study, use of hypothermic machine perfusion (HMP) was investigated in donor livers that had initially been rejected by the originating United Network for Organ Sharing (UNOS) region. Investigators reviewed two groups of patients receiving an isolated primary liver transplantation. A total of 31 patients in the intervention arm received HMP livers and 30 patients in the control arm received static cold-stored (SCS) livers that were matched for donor age, recipient age, cold ischemic time, donor risk index and model end-stage liver disease (MELD) score. Read More ›
A retrospective review of United Network for Organ Sharing (UNOS) data from January 1, 2005 through to March 31, 2011 was conducted in order to evaluate the impact of machine perfusion (MP) on early kidney transplant function in the US. Within the overall cohort, there were 19,372 (37.9%) patients who received organs that underwent MP and 32,351 (62.1%) patients who received static cold storage (SCS) organs. The overall use of expanded criteria donor kidneys was 19.3% (n = 10,077) and overall use of donated after cardiac death kidneys was 12.1% (n = 6,279). Read More ›