A recent review article by Karangwa et al. looked at the current and ongoing evidence for hypothermic machine perfusion (HMP) in liver transplantation.
They presented the following results of studies:
- HMP had significantly better post-operative liver function compared to static cold storage (SCS)
- There is reduced injury to complex I in HMP preserved livers as measured by FMN loss in HMP preserved livers
- Better ATP preservation in HMP livers compared to SCS
- Reduced biliary complications with HMP
Overall, they concluded that HMP has been demonstrated to improve graft survival and reduce complications, as well as the underlying mechanisms of protection such as improving complex I-V function and ATP recharging.
Read the full article here: https://doi.org/10.1016/j.ijsu.2020.04.057
Check out the most recent posts
July 29, 2022 to August 3, 2022 San Diego, CA Produced by the Transplant Life Foundation, the Transplant Games honor the lasting legacy of donors who gave the ultimate gift of life, highlight the need for and importance of organ, eye, and tissue donation, celebrate...
HMP of Kidneys Compensates for Extended Storage Time: A Single Intervention With a Significant Impact
A study out of Poland by Kruszyna and Richter sought to determine whether with increased cold ischemic times (CIT) and increased use of extended criteria donors (ECD), would hypothermic machine perfusion (HMP) still have the potential to improve outcomes in kidney...
In a multicenter, randomized, controlled trial by Van Rijn, et al, they sought to compare hypothermic oxygenated machine perfusion with static cold storage in liver transplantation from donation after cardiac death (DCD) donors. In this trial, they included 156...
A multicenter retrospective study by de Sandes-Freitas et al. sought to determine the national rate of delayed graft function (DGF) and the associated risk factors with DGF. They studied 8,657 single deceased donor kidney transplants between January 2014 and December...