Hypothermic Machine Perfusion in Liver Transplantation

A recent review article by Karangwa et al. looked at the current and ongoing evidence for hypothermic machine perfusion (HMP) in liver transplantation.

They presented the following results of studies:

  • HMP had significantly better post-operative liver function compared to static cold storage (SCS)
  • There is reduced injury to complex I in HMP preserved livers as measured by FMN loss in HMP preserved livers
  • Better ATP preservation in HMP livers compared to SCS
  • Reduced biliary complications with HMP

Overall, they concluded that HMP has been demonstrated to improve graft survival and reduce complications, as well as the underlying mechanisms of protection such as improving complex I-V function and ATP recharging.

Read the full article here: https://doi.org/10.1016/j.ijsu.2020.04.057

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