Outcome of liver transplantation with grafts from DBD donors treated with D-HOPE

In a single center, retrospective cohort study by Patrono et al., they sought to compare the effects of dual hypothermic oxygenated machine perfusion (D-HOPE) and static cold storage (SCS) on graft survival in liver transplant with grafts from extended criteria donation after brain death (ECD-DBD) grafts. This trial included 844 patients (121 D-HOPE and 723 SCS) with a primary outcome of early allograft failure (EAF), as defined by listing for retransplantation or patient death for any cause within 90 days of transplant.

Their results found:

  • D-HOPE was associated with a significant reduction of:
    • EAF (OR:0.24)
    • Dindo-Clavien grade ≥3 complications (OR: 0.57)
    • Comprehensive complication index (mean reduction 7.20 points)
  • Ischemic cholangiopathy severity was significantly lower in the D-HOPE group
  • D-HOPE had a significant improvement in both graft and patient survival

Overall, they concluded that this study showed D-HOPE of livers from DBD donors is associated with a significant reduction of postoperative complications and EAF, leading to improved patient and graft survival.  They indicated that their findings prompt a wider adoption of D-HOPE in clinical practice.

Read the full article here: https://doi.org/10.1111/ajt.16996

The Latest

Check out the most recent posts

Gift of Hope Collaboration—Kidney Perfusion Videos

In collaboration with Gift of Hope Organ & Tissue Donor Network, we're proud to provide two videos around kidney perfusion on the Organ Recovery Systems Client Community! Kidney Perfusion Improves Transplant Success describes how Gift of Hope uses HMP technology...