In 2023, Malinoski et al. published the results from a pragmatic, adaptive, prospective, randomized trial that was conducted between August 10, 2017, and May 21, 2020 involving six OPOs in the US. They sought to determine whether targeted mild hypothermia is as effective as hypothermic machine perfusion (HMP) of kidneys obtained from brain dead donors. They compared the outcomes from kidney transplants of 1349 kidneys divided into 3 groups: hypothermia group (359 kidneys), hypothermic machine perfusion (511 kidneys), and a combination of both hypothermia and HMP (479 kidneys).
Overall, they found that:
- Incidence of DGF was lower in the HMP group compared to the hypothermia group (19% vs. 30%)
- Odds ratios showed that the non-inferiority of hypothermia to HMP was not established (OR 1.56)
- One year graft survival was similar across all three groups.
They concluded that HMP was superior to hypothermia alone in reducing the incidence of delayed graft function, and that a combination of both therapies was not superior to HMP alone.
Read the full article here: www.nejm.org/doi/10.1056/NEJMoa2118265
Check out the most recent posts
Overcoming the longest cold ischemia time seen in Korea using HMP in deceased donor kidney transplantation
Kim et al. reported on a deceased donor kidney transplant case that had the longest reported cold ischemic time (CIT) in Korea which was facilitated by using hypothermic machine perfusion (HMP). A 54 year old male marginal deceased donor (Korean Kidney Donor Profile...
Organ Recovery Systems (ORS) is honored to announce that UC Health, a Continued Access site in PILOT clinical trial has set a record in 2023 for most transplants in the US! We are thankful for our ongoing collaboration with UC Health and their success using LifePort...
Portable hypothermic oxygenated machine perfusion for organ preservation in liver transplantation (PILOT™): A randomized, open-label, clinical trial*
Panayotova et al. published a multicenter, randomized, non inferiority trial which sought to compare liver preservation using the LifePort Liver Transporter to the standard of care, static cold storage. The study included 142 liver transplant procedures from 9 US...
Brief Bubble and Intermittent Surface Oxygenation Is a Simple and Effective Alternative for Membrane Oxygenation During Hypothermic Machine Perfusion in Kidneys
A study by Darius et al. sought to evaluate the use of direct bubble and intermittent surface oxygenation during continuous HMP as an alternative to using a membrane oxygenator. They evaluated the renal flow, resistance and concentration of pO2 in the perfusate as...