Portable hypothermic oxygenated machine perfusion for organ preservation in liver transplantation (PILOT™): A randomized, open-label, clinical trial*

Clinical Evidence, News

Portable hypothermic oxygenated machine perfusion for organ preservation in liver transplantation (PILOT™): A randomized, open-label, clinical trial*

Portable hypothermic oxygenated machine perfusion for organ preservation in liver transplantation (PILOT™): A randomized, open-label, clinical trial*

Panayotova et al. published a multicenter, randomized, noninferiority trial which sought to compare liver preservation using the LifePort Liver Transporter to the standard of care, static cold storage.  The study included 142 liver transplant procedures from 9 US centers, and compared outcomes such as early allograft dysfunction, L-GrAFT7 score, primary nonfunction, biliary strictures, and non-anastomotic biliary strictures.

They found that:

  • Lower incidence of EAD in HMP-O2
  • Risk of graft failure as predicted by L-GrAFT7 was lower in HMP-O2
  • Lower incidence of PNF in HMP-O2
  • Lower incidence of biliary strictures in HMP-O2
  • Severe non-infectious adverse events were almost 3x more common in SCS

They concluded that HMP-O2 with LifePort Liver Transporter is safe and efficacious for liver graft preservation compared to SCS.

Read the full article here: https://journals.lww.com/hep/abstract/9900/portable_hypothermic_oxygenated_machine_perfusion.678.aspx

Tagged In:

HMP, Liver, Oxygen

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