Matched pair analysis of the effect of longer hypothermic machine perfusion time on kidney transplant outcomes

Clinical Evidence

Matched pair analysis of the effect of longer hypothermic machine perfusion time on kidney transplant outcomes

Matched pair analysis of the effect of longer hypothermic machine perfusion time on kidney transplant outcomes

This single-center study published in World Journal of Transplantation looked at deceased donor kidney transplant pairs occurring at University of Saskatchewan between 2012 and 2021. Both donor kidneys were placed on LifePort Kidney Transporter prior to transplant. Kidneys transplanted first (Kidney 1) had a median pump time of 5.2 hours, and those transplanted second (Kidney 2) had a median pump time of 10.8 hours.

The investigators found:

  • Higher incidence of DGF in Kidney 1 compared to Kidney 2
  • Freedom from biopsy-proven acute rejection was observed at a higher incidence in Kidney 2
  • Graft survival was longer for Kidney 2 compared to Kidney 1.

The authors hypothesize that longer pump times offer additional anti-inflammatory factors and reduce vasoconstricting peptides, allowing cells and tubules to better recover from ischemic injury.

Read the full article here: https://www.wjgnet.com/2220-3230/full/v14/i3/95233.htm

Tagged In:

DGF, Graft Survival, HMP, Kidney

The Latest

Check out the most recent posts

Kelley, Clinical and Technical Advisor

Kelley, Clinical and Technical Advisor

Before I joined Organ Recovery Systems last September as a Clinical and Technical Advisor, I was a Surgical Recovery Specialist in kidney and research organs at LifeSource, which is where I met ORS team members. The more I talked to them, the more I realized my...

The Interconnected Road to Organ Preservation Innovation

The Interconnected Road to Organ Preservation Innovation

Author: Perry Turner May 13, 2026This Community Pulse Blog was originally published on the Association of Organ Procurement Organization’s (AOPO) website on 5/12/26. View the original version here.  When the average person envisions organ donation or transplantation,...

Perspective: Full Circle on the Trail

Perspective: Full Circle on the Trail

Author: Katie Slaughter May 4, 2026During National Donate Life Month and throughout the year, Organ Recovery Systems (ORS) supports our transplant partners with sponsorships of events, fun runs, galas and more. This year, one of the events ORS sponsored was the...