A Retrospective Propensity Score Matched Analysis Reveals Superiority of Hypothermic Machine Perfusion over Static Cold Storage in Deceased Donor Kidney Transplantation

Gasteiger et al. performed a retrospective analysis of all kidney transplant recipients between August 2015 and December of 2019 performed at the Medical University of Innsbrook. The study included 347 patients of which 124 of the recipient organs had been preserved by hypothermic machine perfusion (HMP) and the remaining organs were preserved by static cold storage (SCS).

Their study found that in their propensity score matched cohort:

  • Delayed graft function (DGF) was significantly less frequent following HMP than SCS (31.1% vs 64.1%)
    • This was found in both ECD and SCD donors
  • HMP resulted in a 51.5% reduction of the risk of DGF

They concluded that HMP impressively halved the DGF rate compared to SCS kidneys after similar periods of cold ischemic time.  They also noted that the effects of HMP may in fact be more significant and impactful than expected and that for the purpose of achieving the most optimal kidney preservation, HMP should be the preferred technique.

Read the full article here: https://dx.doi.org/10.3390%2Fjcm9072311

Tagged In:

DGF, ECD, HMP, Kidney, SCD

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