Gasteiger et al. performed a retrospective analysis of all kidney transplant recipients between August 2015 and December of 2019 performed at the Medical University of Innsbrook. The study included 347 patients of which 124 of the recipient organs had been preserved by hypothermic machine perfusion (HMP) and the remaining organs were preserved by static cold storage (SCS).
Their study found that in their propensity score matched cohort:
- Delayed graft function (DGF) was significantly less frequent following HMP than SCS (31.1% vs 64.1%)
- This was found in both ECD and SCD donors
- HMP resulted in a 51.5% reduction of the risk of DGF
They concluded that HMP impressively halved the DGF rate compared to SCS kidneys after similar periods of cold ischemic time. They also noted that the effects of HMP may in fact be more significant and impactful than expected and that for the purpose of achieving the most optimal kidney preservation, HMP should be the preferred technique.
Read the full article here: https://dx.doi.org/10.3390%2Fjcm9072311
Check out the most recent posts
Novel Oxygenation Technique for Hypothermic Machine Perfusion of Liver Grafts: Validation in Porcine Donation after Cardiac Death (DCD) Liver Model
In a pre-clinical study using a porcine DCD model, Panayotova et al. sought to validate the novel technique of oxygen “pre-charge” for hypothermic machine perfusion (HMP) using the LifePort Liver Transporter. The study evaluated the effects of this preservation method...
David’s Transplant Journey
In this powerful video, we meet David, a liver recipient who shares his journey of needing a liver transplant. David speaks about the emotional and physical toll of waiting for a liver to become available, not knowing when or if he would receive that call. David takes...
Changing liver utilization and discard rates in clinical transplantation in the ex-vivo machine preservation era
A recent review article by Azizieh et al. focused on the implementation of ex-vivo machine preservation and how it might change the perception of organ acceptability. By focusing on machine perfusion, they explored the effects of the different modalities on outcomes...
Therapeutic Hypothermia or Hypothermic Machine Perfusion (HMP) which is best for Kidney Transplant Outcomes?
In 2023, Malinoski et al. published the results from a pragmatic, adaptive, prospective, randomized trial that was conducted between August 10, 2017, and May 21, 2020 involving six OPOs in the US. They sought to determine whether targeted mild hypothermia is as...