Cold Ischemia Time and Delayed Function in Kidney Transplantation: A Paired Kidney Analysis

Clinical Evidence

Cold Ischemia Time and Delayed Function in Kidney Transplantation: A Paired Kidney Analysis

Cold Ischemia Time and Delayed Function in Kidney Transplantation: A Paired Kidney Analysis

This retrospective cohort study by Husain et al. analyzed US registry data. Investigators identified kidney pairs from the same donor where there was a notable difference in CIT between the kidneys.

The results showed that:

  • Out of 25,831 kidney pairs, 71% had concordant DGF outcomes, 16% had only the longer-CIT kidney with DGF, and 13% had only the shorter-CIT kidney with DGF.
  • Longer-CIT is associated with increased risk of DGF, even for small differences in CIT.
  • Longer-CIT kidneys that were pumped were less likely to develop DGF than shorter-CIT kidneys that were not pumped.

The authors concluded that pumping kidneys may mitigate and even overcome the adverse consequences of prolonged CIT on the risk of DGF.

Read the article here: https://journals.lww.com/transplantjournal/pages/articleviewer.aspx?year=2024&issue=09000&article=00020&type=Abstract

 

Tagged In:

CIT, DGF, HMP, Kidney

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