Hypothermic machine perfusion for liver graft preservation

A recent review article by Amin et al. focused on the mechanistic actions of hypothermic machine perfusion (HMP) in liver graft preservation, the clinical literature of HMP in liver transplantation and the future directions of clinical application of HMP in liver transplantation.

They highlighted the following key points:

  • Due to its ability to provide oxygen and nutrients and remove toxic metabolic waste products, HMP leads to less severe ischemic reperfusion injury
  • Current clinical evidence has shown that HMP provides decreased biliary complications and lower early allograft dysfunction (EAD) rates which leads to increased liver graft survival
  • Recent studies looking at viability assessment during HMP show promising results, such as those analyzing flavin mononucleotide (FMN)

Overall, they concluded that HMP for liver graft preservation has the potential to increase the number of liver transplants and improve results with livers from donors after circulatory death (DCD) and extended criteria donors after brain death (DBD).

Read the full article here: https://journals.lww.com/co-transplantation/Citation/2022/04000/Hypothermic_machine_perfusion_for_liver_graft.3.aspx

Tagged In:

DCD, EAD, ECD, HMP, Liver

The Latest

Check out the most recent posts

ASTS Winter Symposium

ASTS Winter Symposium

January 16 - January 19, 2025 Sheraton Grand Hotel5594 W Wild Horse Pass BlvdPhoenix, AZ 85226 The American Society of Transplant Surgeons is dedicated to saving and improving the lives of others through the power of organ donation and transplant surgery. This event...

NATCO Annual Meeting

NATCO Annual Meeting

February 23 - February 26, 2025 Hyatt Regency Hill Country Resort & Spa 9800 Hyatt Resort DrSan Antonio, TX 78251 NATCO is dedicated to advancing education, promoting certifications, and furthering the professional development of donation and transplant...