Machine Perfusion in Liver Transplantation: A Systematic Review and Meta-Analysis

A systematic review and meta-analysis by Jakubauskas et al. aimed to review the literature reporting liver transplant outcomes when using normothermic machine perfusion (NMP) or hypothermic machine perfusion (HMP) for organ preservation compared to static cold storage (SCS). They included 15 studies in the qualitative synthesis (NMP n=6, HMP n=9). Due to the diversity of the NMP studies, only studies investigative HMP (n=9) were included in the meta-analysis.

From these studies they found:

The potential of NMP to reduce graft injury and lower liver discard rate
That HMP reduces
- Rate of EAD
- Total biliary complications
- Non-anastomotic biliary strictures
HMP showed a tendency towards improved graft and patient survival at 12-months, though they failed to reach statistical significance

Overall, they concluded that NMP has the potential to reduce graft injury and lower liver graft discard rate. As well as the use of HMP reduces the rate of EAD and non-anastomotic biliary strictures compared to SCS.

Read the full article here: https://www.karger.com/Article/FullText/519788

Tagged In:

Clinical, EAD, Graft Survival, HMP, Liver

The Latest

Check out the most recent posts

LifePort Liver Transporter by Organ Recovery Systems Wins Fast Company’s 2023 Innovation by Design Award in the ‘Health’ Category

News

Organ Recovery Systems (ORS) is honored to announce that its LifePort Liver Transporter was selected as the winner in the ‘Health’ category in Fast Company’s Innovation by Design Awards for 2023. The Innovation by Design Awards, which can be found in the September...

ISODP Congress

Congresses & Events

October 18, 2023 to October 21, 2023 Mandalay Bay3950 Las Vegas BlvdLas Vegas, NV 89119 The International Society for Donation and Transplantation is the organization advancing donation through science, developing professionals and inspiring networks supporting organ...

The first use of hypothermic machine perfusion in Korea to recover a procured kidney graft and prevent prolonged cold ischemic time: a case report

Clinical Evidence

Shin et al. reported on the first deceased donor kidney transplant case using hypothermic machine perfusion (HMP) on Jeju Island, Korea. A single deceased donor with several hours of marginal oxygen saturation had both kidneys assigned to Jeju Island. Due to...

Novel Oxygenation Technique for Hypothermic Machine Perfusion of Liver Grafts: Validation in Porcine Donation after Cardiac Death (DCD) Liver Model

Clinical Evidence

In a pre-clinical study using a porcine DCD model, Panayotova et al. sought to validate the novel technique of oxygen “pre-charge” for hypothermic machine perfusion (HMP) using the LifePort Liver Transporter. The study evaluated the effects of this preservation method...