Machine Perfusion or Cold Storage in Deceased-Donor Kidney Transplantation

In 2009, Moers et al. published the largest ever randomized controlled trial comparing paired kidneys that were either subjected to hypothermic machine perfusion (HMP) or cold storage (CS). This study included 336 kidney pairs that were randomized to either the HMP group or CS group.

Overall, they found that:

  • HMP significantly reduced the risk of delayed graft function (DGF)
  • Duration of DGF was shorter in the HMP group
  • One-year graft survival was significantly higher in the HMP group

They concluded that hypothermic machine perfusion reduces the incidence of DGF as well as reducing the risk of graft failure in the first year, resulting in improved 1-year graft survival compared to kidneys preserved by static cold storage.

Read the full article here: https://www.nejm.org/doi/full/10.1056/NEJMoa0802289

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