In 2009, Moers et al. published the largest ever randomized controlled trial comparing paired kidneys that were either subjected to hypothermic machine perfusion (HMP) or cold storage (CS). This study included 336 kidney pairs that were randomized to either the HMP group or CS group.
Overall, they found that:
- HMP significantly reduced the risk of delayed graft function (DGF)
- Duration of DGF was shorter in the HMP group
- One-year graft survival was significantly higher in the HMP group
They concluded that hypothermic machine perfusion reduces the incidence of DGF as well as reducing the risk of graft failure in the first year, resulting in improved 1-year graft survival compared to kidneys preserved by static cold storage.
Read the full article here: https://www.nejm.org/doi/full/10.1056/NEJMoa0802289
Check out the most recent posts
ILTS Annual CongressMay 5, 2021 to May 8, 2021 Lutfi Kirdar International Convention and Exhibition CenterIstanbul34367 HarbiyeTurkey The goal of the ILTS Annual Congress is to provide an excellent platform to deepen the education and knowledge of scientists,...
Renal Resistance Trend During HMP Is More Predictive of Postoperative Outcome Than Biopsy ScoreBissolati et al. sought evaluate the prognostic role of renal resistance (RR) valued during hypothermic machine perfusion (HMP) on postoperative outcome. They analyzed 65...
The Impact of Hypothermic Pulsatile Machine Perfusion Versus Static Cold Storage on Delayed Graft Function
The Impact of Hypothermic Pulsatile Machine Perfusion Versus Static Cold Storage on Delayed Graft FunctionA retrospective paired kidney study by de Sandes-Freitas et al. sought to determine whether hypothermic machine perfusion (HMP) was beneficial in their unique...
Hypothermic Machine Perfusion in Liver TransplantationA recent review article by Karangwa et al. looked at the current and ongoing evidence for hypothermic machine perfusion (HMP) in liver transplantation. They presented the following results of studies: HMP had...