A recent paper published in Brazil by Tedesco-Silva et al. sought to determine the impact of hypothermic machine perfusion (HMP) on kidneys with a high incidence of delayed graft function (DGF). They performed a paired kidney analysis of 80 kidney pairs and evaluated DGF as the primary outcome, as well as secondary outcomes such as duration of DGF and hospital stay.
They found that:
- The incidence of DGF was lower in the continuous machine perfusion group (45% vs 61%)
- Renal function recovery occurred earlier in the machine perfusion group
- There were similar outcomes in terms of duration of DGF and length of hospital stay
Overall, they concluded that in a cohort of recipients with high incidence of DGF, the use of continuous machine perfusion is associated with a reduced risk of DGF compared to static cold storage.
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