A recent paper published in Brazil by Tedesco-Silva et al. sought to determine the impact of hypothermic machine perfusion (HMP) on kidneys with a high incidence of delayed graft function (DGF). They performed a paired kidney analysis of 80 kidney pairs and evaluated DGF as the primary outcome, as well as secondary outcomes such as duration of DGF and hospital stay.   

They found that: 

• The incidence of DGF was lower in the continuous machine perfusion group (45% vs 61%) 

• Renal function recovery occurred earlier in the machine perfusion group  
• There were similar outcomes in terms of duration of DGF and length of hospital stay 

Overall, they concluded that in a cohort of recipients with high incidence of DGF, the use of continuous machine perfusion is associated with a reduced risk of DGF compared to static cold storage.

Read the full article here: https://journals.lww.com/transplantationdirect/pages/articleviewer.aspx?year=2017&issue=05000&article=00004&type=Fulltextwww.ncbi.nlm.nih.gov/pmc/articles/PMC10332281/