Moser et al. sought to determine whether the short warm ischemic time in living donor kidney (LDK) transplantation causes damage to the kidney, and whether these kidneys could benefit from the use of hypothermic machine perfusion (HMP). In their initial experiment, they compared the results of 16 LDK kidneys that were placed on HMP to historical controls.
They found that:
- The perfusate had significant injury markers in the perfusates of the LDK kidneys
- Suggesting damage during the normothermic ischemia period
- Creatinine clearance was significantly higher in the HMP group at post-operative day 2 and persisted at one-year post-transplant
- The vascular resistance improved during HMP and this persisted in the early post-operative period
- The resistive indices were significantly less for the HMP group than the static cold storage group
They noted that the significant levels of injury markers in perfusate of the LDK after a short preservation time suggests that injury does occur in this procedure. They concluded that their early experience suggests that HMP may be beneficial to LDK in terms of early changes to vascular resistance and early function.
Read the full article here: https://onlinelibrary.wiley.com/doi/full/10.1111/tri.12964
Check out the most recent posts
A multicenter retrospective study by de Sandes-Freitas et al. sought to determine the national rate of delayed graft function (DGF) and the associated risk factors with DGF. They studied 8,657 single deceased donor kidney transplants between January 2014 and December...
Savoye et al. performed a retrospective analysis to assess early outcomes of kidney transplants in the French controlled donation after circulatory death (cDCD) program by comparing them to transplants from donation after brain death (DBD) donors in the French...
April 19, 2021 to April 22, 2021 2021 Virtual Transplant Management ForumTransplant administrators from across the country attend the UNOS Transplant Management Forum each year for its educational sessions and networking opportunities. While many of the sessions are...
Evaluation of outcomes in renal transplantation with hypothermic machine perfusion for the preservation of kidneys from expanded-criteria donors
A recently released article by Savoye et al. used the data collected by The French National Transplant Registry (CRISTAL) following the implementation of a nationwide hypothermic machine perfusion (HMP) program for extended criteria donor (ECD) kidney transplants. The...