An abstract presented at the American Transplant Congress (ATC) in May 2013 by Dr. Victoria Gomez et al. evaluated the budgetary impact and incremental cost-effectiveness of hypothermic machine perfusion compared with static cold storage.1
Kidneys transplanted from expanded criteria donors (ECDs) have a significantly increased incidence of delayed graft function (DGF) compared with kidneys from standard criteria donors,2 which increases post-operative costs due to prolonged hospital stay, the need for dialysis and additional diagnostic procedures.
The short-term cost-effectiveness of ECD transplantation using machine perfusion was reviewed using a probabilistic theoretical decision-tree. The budgetary impact and incremental cost-effectiveness ratio was estimated in terms of the number of DGF and primary non-function (PNF) cases saved by using machine perfusion instead of static cold storage.
The budgetary impact per patient of using machine perfusion was €610, but the incremental cost-effectiveness ratio showed a €16,476 saving for each case of initial graft function achieved. With published data showing that machine perfusion reduces the risk of DGF and PNF compared with static cold storage,3 this study has shown that machine perfusion is a cost effective option despite the initial budgetary impact.
1. Gomez V et al. Economic impact of pulsatile hypothermic perfusion in an expanded criteria donor transplant program. Analysis of the first year since its introduction. Abstract presented at American Transplant Congress, Seattle USA, May 18–22, 2013.
2. Johnson TD et al. Sensitivity of expanded-criteria donor kidneys to cold ischemia time. Clin Transpl 2004;18:28–32.
3. Moers C et al. Machine perfusion or cold storage in deceased-donor kidney transplantation. N Engl J Med 2009;360:7–19.
Check out the most recent posts
ILTS Annual CongressMay 5, 2021 to May 8, 2021 Lutfi Kirdar International Convention and Exhibition CenterIstanbul34367 HarbiyeTurkey The goal of the ILTS Annual Congress is to provide an excellent platform to deepen the education and knowledge of scientists,...
Renal Resistance Trend During HMP Is More Predictive of Postoperative Outcome Than Biopsy ScoreBissolati et al. sought evaluate the prognostic role of renal resistance (RR) valued during hypothermic machine perfusion (HMP) on postoperative outcome. They analyzed 65...
The Impact of Hypothermic Pulsatile Machine Perfusion Versus Static Cold Storage on Delayed Graft Function
The Impact of Hypothermic Pulsatile Machine Perfusion Versus Static Cold Storage on Delayed Graft FunctionA retrospective paired kidney study by de Sandes-Freitas et al. sought to determine whether hypothermic machine perfusion (HMP) was beneficial in their unique...
Hypothermic Machine Perfusion in Liver TransplantationA recent review article by Karangwa et al. looked at the current and ongoing evidence for hypothermic machine perfusion (HMP) in liver transplantation. They presented the following results of studies: HMP had...