A single-center paired kidney study by Dion et al. where 15 kidneys were randomly assigned to the cold storage group and the contralateral kidney was assigned to the hypothermic machine perfusion sought to examine whether machine perfusion has an effect on vascular indices post transplantation as well as long term survival. They found that:
- Using doppler ultrasonography to examine resistive indices
- HMP had significantly lower resistive indices
- Survival outcomes
- HMP had significantly better eGFR even 2 years post-transplant
Overall, the HMP preserved kidneys had improved vascular resistance after transplantation which had an effect on long-term allograft function in recipients of DCD kidneys.
Read the full article here: https://www.ncbi.nlm.nih.gov/pubmed/25327417
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