Intermittent Surface Oxygenation Results in Similar Mitochondrial Protection and Maintenance of Aerobic Metabolism as Compared to Continuous Oxygenation during Kidney HMP

Clinical Evidence

Intermittent Surface Oxygenation Results in Similar Mitochondrial Protection and Maintenance of Aerobic Metabolism as Compared to Continuous Oxygenation during Kidney HMP

Intermittent Surface Oxygenation Results in Similar Mitochondrial Protection and Maintenance of Aerobic Metabolism as Compared to Continuous Oxygenation during Kidney HMP

A study by Darius et al. evaluated the metabolic effect of a short interruption of surface oxygenation compared to continuous surface and membrane oxygenation in a pig kidney model. They looked at ATP levels as well as the pO2 measures, renal flow and resistance, and metabolic perfusate and tissue profiles.

They found that:

  • Direct bubble oxygenation of the perfusion fluid by minimum 15 min was as efficient as membrane oxygenation
  • All groups had similar renal flow
  • All groups had similar perfusate profiles at 4h 30m and end of HMP
  • At the end of HMP, the continuous oxygenated group had higher FMN values
  • Histological tissue evaluation showed no significant difference between all groups

Overall, intermittent surface oxygenation might be an effective oxygenation strategy to recondition mitochondria during HMP as compared with membrane-oxygenation. This method has the potential to reduce the ecological and economic impact of active oxygenation by eliminating the need for a membrane oxygenator and oxygen source during transport.

Read the full article here: https://www.mdpi.com/2077-0383/12/11/3731

Tagged In:

ATP, HMP, Kidney, Oxygen

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