Machine Perfusion versus Cold Storage for Preservation of Kidneys from Expanded Criteria Donors after Brain Death

In an article based on the expanded criteria donor (ECD) subset from the machine perfusion trial, Treckmann et al. analyzed 91 donors where one kidney was assigned to the machine perfusion (MP) group and the contralateral kidney was preserved by static cold storage (CS).

They found that:

MP significantly reduced the risk of DGF
Incidence of PNF was 4x higher in the CS group compared to the MP group
One-year graft survival was significantly higher in the MP group

Overall, they found that MP reduces the risk of DGF and improves 1-year graft survival and function in ECD kidneys. They believe that all ECD kidneys should be machine perfused because in the first year alone 12% more grafts could be saved.

Read the full article here: https://doi.org/10.1111/j.1432-2277.2011.01232.x

Tagged In:

ECD, Graft Survival, HMP

The Latest

Check out the most recent posts

Overcoming the longest cold ischemia time seen in Korea using HMP in deceased donor kidney transplantation

Clinical Evidence, News

Kim et al. reported on a deceased donor kidney transplant case that had the longest reported cold ischemic time (CIT) in Korea which was facilitated by using hypothermic machine perfusion (HMP). A 54 year old male marginal deceased donor (Korean Kidney Donor Profile...

Local12—Machine perfusion leading to more organ viability for liver transplants

News

Organ Recovery Systems (ORS) is honored to announce that UC Health, a Continued Access site in PILOT clinical trial has set a record in 2023 for most transplants in the US! We are thankful for our ongoing collaboration with UC Health and their success using LifePort...

Portable hypothermic oxygenated machine perfusion for organ preservation in liver transplantation (PILOT™): A randomized, open-label, clinical trial*

Clinical Evidence, News

Panayotova et al. published a multicenter, randomized, noninferiority trial which sought to compare liver preservation using the LifePort Liver Transporter to the standard of care, static cold storage. The study included 142 liver transplant procedures from 9 US...

Brief Bubble and Intermittent Surface Oxygenation Is a Simple and Effective Alternative for Membrane Oxygenation During Hypothermic Machine Perfusion in Kidneys

Clinical Evidence

A study by Darius et al. sought to evaluate the use of direct bubble and intermittent surface oxygenation during continuous HMP as an alternative to using a membrane oxygenator. They evaluated the renal flow, resistance and concentration of pO2 in the perfusate as...