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The Evolution of Kidney Graft Preservation Through the Years
In this review, the authors provide a comprehensive overview of the evolution of kidney graft preservation methods, detailing the transition from traditional SCS to more advanced technologies, such as HMP and HOPE. HMP has demonstrated advantages in reducing DGF and...
Impact of Warm Ischemia Time on DCD Kidney Transplant Outcomes
This single-center retrospective review by Alghannam et al. looked at the impact of functional warm ischemic time (fWIT) in controlled DCD donors by comparing donor/recipient characteristics and outcomes between high fWIT (>60min), low fWIT (<60min), and DBD...
Cold Ischemia Time and Delayed Function in Kidney Transplantation: A Paired Kidney Analysis
This retrospective cohort study by Husain et al. analyzed US registry data. Investigators identified kidney pairs from the same donor where there was a notable difference in CIT between the kidneys. The results showed that: Out of 25,831 kidney pairs, 71% had...
Use of Machine Perfusion to Increase the Number of Expanded Criteria Deceased Donor Kidney Transplants: A Pharmacoeconomic Analysis
A recent pharmacoeconomic study from Brazil by Tedesco Silva Junior et al. sought to evaluate the cost-effectiveness and budgetary impact of incorporating hypothermic machine perfusion (HMP) for preserving extended criteria donor (ECD) kidneys. They found that...
Overcoming the longest cold ischemia time seen in Korea using HMP in deceased donor kidney transplantation
Kim et al. reported on a deceased donor kidney transplant case that had the longest reported cold ischemic time (CIT) in Korea which was facilitated by using hypothermic machine perfusion (HMP). A 54 year old male marginal deceased donor (Korean Kidney Donor Profile...
Local12—Machine perfusion leading to more organ viability for liver transplants
Organ Recovery Systems (ORS) is honored to announce that UC Health, a Continued Access site in PILOT clinical trial has set a record in 2023 for most transplants in the US! We are thankful for our ongoing collaboration with UC Health and their success using LifePort...
Portable hypothermic oxygenated machine perfusion for organ preservation in liver transplantation (PILOT™): A randomized, open-label, clinical trial*
Panayotova et al. published a multicenter, randomized, noninferiority trial which sought to compare liver preservation using the LifePort Liver Transporter to the standard of care, static cold storage. The study included 142 liver transplant procedures from 9 US...
Brief Bubble and Intermittent Surface Oxygenation Is a Simple and Effective Alternative for Membrane Oxygenation During Hypothermic Machine Perfusion in Kidneys
A study by Darius et al. sought to evaluate the use of direct bubble and intermittent surface oxygenation during continuous HMP as an alternative to using a membrane oxygenator. They evaluated the renal flow, resistance and concentration of pO2 in the perfusate as...
Intermittent Surface Oxygenation Results in Similar Mitochondrial Protection and Maintenance of Aerobic Metabolism as Compared to Continuous Oxygenation during Kidney HMP
A study by Darius et al. evaluated the metabolic effect of a short interruption of surface oxygenation compared to continuous surface and membrane oxygenation in a pig kidney model. They looked at ATP levels as well as the pO2 measures, renal flow and resistance, and...
First clinical kidney transplantation series using brief bubble and direct surface oxygenation as alternative for membrane oxygenation during HMP
A study by Darius et al. reported on the first 5 cases of using the method of bubble and intermittent surface oxygenation during HMP in human renal transplantation. This case study provided information on 3 DCD donors of which 5 of the 6 kidneys were allocated to...
LifePort Liver Transporter by Organ Recovery Systems Achieves 100 Perfused Livers in Continued Access Study
Organ Recovery Systems (ORS) is proud to announce that 100 donor livers have been successfully transplanted after being preserved using LifePort® Liver Transporter (LLT) with Vasosol® at approved centers under the Continued Access arm of the PILOT™ (Perfusion to...
Decreased incidence of DGF in a high-DGF population
A recent paper published in Brazil by Tedesco-Silva et al. sought to determine the impact of hypothermic machine perfusion (HMP) on kidneys with a high incidence of delayed graft function (DGF). They performed a paired kidney analysis of 80 kidney pairs and evaluated...
LifePort Liver Transporter by Organ Recovery Systems Wins Fast Company’s 2023 Innovation by Design Award in the ‘Health’ Category
Organ Recovery Systems (ORS) is honored to announce that its LifePort Liver Transporter was selected as the winner in the ‘Health’ category in Fast Company’s Innovation by Design Awards for 2023. The Innovation by Design Awards, which can be found in the September...
The first use of hypothermic machine perfusion in Korea to recover a procured kidney graft and prevent prolonged cold ischemic time: a case report
Shin et al. reported on the first deceased donor kidney transplant case using hypothermic machine perfusion (HMP) on Jeju Island, Korea. A single deceased donor with several hours of marginal oxygen saturation had both kidneys assigned to Jeju Island. Due to...
Novel Oxygenation Technique for Hypothermic Machine Perfusion of Liver Grafts: Validation in Porcine Donation after Cardiac Death (DCD) Liver Model
In a pre-clinical study using a porcine DCD model, Panayotova et al. sought to validate the novel technique of oxygen “pre-charge” for hypothermic machine perfusion (HMP) using the LifePort Liver Transporter. The study evaluated the effects of this preservation method...
David’s Transplant Journey
In this powerful video, we meet David, a liver recipient who shares his journey of needing a liver transplant. David speaks about the emotional and physical toll of waiting for a liver to become available, not knowing when or if he would receive that call. David takes...
Changing liver utilization and discard rates in clinical transplantation in the ex-vivo machine preservation era
A recent review article by Azizieh et al. focused on the implementation of ex-vivo machine preservation and how it might change the perception of organ acceptability. By focusing on machine perfusion, they explored the effects of the different modalities on outcomes...
Therapeutic Hypothermia or Hypothermic Machine Perfusion (HMP) which is best for Kidney Transplant Outcomes?
In 2023, Malinoski et al. published the results from a pragmatic, adaptive, prospective, randomized trial that was conducted between August 10, 2017, and May 21, 2020 involving six OPOs in the US. They sought to determine whether targeted mild hypothermia is as...