Decreased rates of delayed graft function in all machine perfused donor kidney types

1 December 2014  //  Clinical Evidence

A retrospective review of United Network for Organ Sharing (UNOS) data from January 1, 2005 through to March 31, 2011 was conducted in order to evaluate the impact of machine perfusion (MP) on early kidney transplant function in the US. Within the overall cohort, there were 19,372 (37.9%) patients who received organs that underwent MP and 32,351 (62.1%) patients who received static cold storage (SCS) organs. The overall use of expanded criteria donor kidneys was 19.3% (n = 10,077) and overall use of donated after cardiac death kidneys was 12.1% (n = 6,279).

Key results

In the paired kidney cohort analysis, delayed graft function (DGF) occurred in 450 (19.7%) patients in the MP group and in 630 (27.5%) patients in the SCS group (p < 0.001). The odds ratio for DGF associated with MP vs. SCS kidneys was 0.61 (p < 0.001). MP was also found to reduce delayed graft function in all donor kidney types.

Cold ischemic time for MP kidneys was 23.4 hours compared with 17.4 hours for SCS kidneys (p < 0.001). No differences were seen in length of hospital stay post-transplant.

Reference

Cannon RM, et al. J Am Coll Surg 2013;216(4):626–33.