Improved rates of delayed graft function with machine perfusion

9 July 2015  //  Clinical Evidence

A retrospective analysis was performed in 93 patients who had received expanded criteria donor (ECD) kidneys over a 4-year period from July 2007 to July 2009. These ECD kidneys were stored via hypothermic machine perfusion (HMP) using a LifePort Kidney Transporter and were compared with an age-matched group who received ECD kidneys between 2003 and 2007, stored using static cold storage (SCS).

Key results

Delayed graft function (DGF) occurred in 17.2% (16/93 patients) of HMP kidneys, with a mean of 6 days, compared with 25.8% (24/93) of SCS kidneys with a mean of 8.1 days. A statistically significant difference in mean serum creatinine was also seen at 1 month (p = 0.0096) and 3 months (p =0.0236). Graft survival rate at 1-year was also shown to be marginally improved in the HMP group (97.85 vs. 96.77%).

The authors concluded that they recommend the use of HMP for ECD kidneys.

Reference

Forde JC, et al. Ir J Med Sci 2014 Dec 5. [Epub ahead of print]