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Early Experience with Hypothermic Machine Perfusion of Living Donor Kidneys
Moser et al. sought to determine whether the short warm ischemic time in living donor kidney (LDK) transplantation causes damage to the kidney, and whether these kidneys could benefit from the use of hypothermic machine perfusion (HMP). In their initial experiment,...
UNOS Transplant Management Forum
April 19, 2021 to April 22, 2021 2021 Virtual Transplant Management ForumTransplant administrators from across the country attend the UNOS Transplant Management Forum each year for its educational sessions and networking opportunities. While many of the sessions are...
Evaluation of outcomes in renal transplantation with hypothermic machine perfusion for the preservation of kidneys from expanded-criteria donors
A recently released article by Savoye et al. used the data collected by The French National Transplant Registry (CRISTAL) following the implementation of a nationwide hypothermic machine perfusion (HMP) program for extended criteria donor (ECD) kidney transplants. The...
Evolving Trends in Machine Perfusion for Liver Transplantation
A recent review article by Dutkowski et al. looked at the evolving evidence for machine perfusion in liver transplantation. They explored the evidence and requirements for both HMP and NMP. They presented the following information: That endpoints need to be strictly...
Renal Resistance Thresholds During HMP and Transplantation Outcomes
Sandal et al. sought to study renal resistance (RR) as an independent predictor of long-term graft survival in kidney transplant recipients whose allografts underwent HMP. They included in their analysis 422 deceased donor kidney transplants of which 59% were from ECD...
ILTS Annual Congress
May 5, 2021 to May 8, 2021 2021 Virtual International CongressThe goal of the ILTS Annual Congress is to provide an excellent platform to deepen the education and knowledge of scientists, surgeons, anesthesiologists, hepatologists, critical care physicians,...
Renal Resistance Trend During HMP Is More Predictive of Postoperative Outcome Than Biopsy Score
Bissolati et al. sought evaluate the prognostic role of renal resistance (RR) valued during hypothermic machine perfusion (HMP) on postoperative outcome. They analyzed 65 kidneys that were preserved using HMP from DCD and ECD donors. They found: Kidneys that reached...
The Impact of Hypothermic Pulsatile Machine Perfusion Versus Static Cold Storage on Delayed Graft Function
A retrospective paired kidney study by de Sandes-Freitas et al. sought to determine whether hypothermic machine perfusion (HMP) was beneficial in their unique situation where the kidney is placed on HMP after a long period of static cold storage (SCS). They compared...
UNOS Insights – The Hypothermic Option
In this UNOS Insights article, learn how Organ Recovery Systems started, what we've done, and where we're going. A company focused on organ preservation products and services, Organ Recovery Systems was formed to develop the interventional hypothermia-inspired organ...
Hypothermic Machine Perfusion in Liver Transplantation
A recent review article by Karangwa et al. looked at the current and ongoing evidence for hypothermic machine perfusion (HMP) in liver transplantation. They presented the following results of studies: HMP had significantly better post-operative liver function compared...
A Retrospective Propensity Score Matched Analysis Reveals Superiority of Hypothermic Machine Perfusion over Static Cold Storage in Deceased Donor Kidney Transplantation
Gasteiger et al. performed a retrospective analysis of all kidney transplant recipients between August 2015 and December of 2019 performed at the Medical University of Innsbrook. The study included 347 patients of which 124 of the recipient organs had been preserved...
Pulsatile Perfusion Reduces the Risk of Delayed Graft Function in Deceased Donor Kidney Transplants, Irrespective of Donor Type and Cold Ischemic Time
In a 2013 publication, Gill et.al. sought to examine two things: the patterns of utilization of hypothermic machine perfusion (HMP) as a function of cold ischemic time (CIT) and donor type as well as the impact of HMP on the risk of DGF by CIT and donor type. They...
LifePort Mobile App Clinical FAQ References
Cited References 1 Gill et al; Pulsatile perfusion reduces the risk of delayed graft function in deceased donor kidney transplants, irrespective of donor type and cold ischemia time; Transplantation; 2014.2 Bissolati et al; Renal Resistance Trend During Hypothermic...
To Pump or Not to Pump: A Comparison of Machine Perfusion vs Cold Storage for Deceased Donor Kidney Transplantation
Cannon et al. performed a retrospective analysis of the UNOS database from January 2005 to March of 2011, which included 52,052 kidney recipients. They found that there was: Significantly less DGF in both Propensity matched cohort (21.1% MP vs 29.1% SCS) Paired kidney...
Machine Perfusion versus Cold Storage for Preservation of Kidneys from Expanded Criteria Donors after Brain Death
In an article based on the expanded criteria donor (ECD) subset from the machine perfusion trial, Treckmann et al. analyzed 91 donors where one kidney was assigned to the machine perfusion (MP) group and the contralateral kidney was preserved by static cold storage...
Machine Perfusion Decreases Delayed Graft Function in Donor Grafts With High Kidney Donor Profile Index
In the era of KDPI, Montenovo et al. sought to assess the impact of the use of machine perfusion (MP) on the incidence of delayed graft function (DGF) in the different groups of kidney grafts classified by kidney donor profile index (KDPI). They used the UNOS database...
Improved post-transplant resistive indices and long-term function in DCD kidneys preserved by HMP
A single-center paired kidney study by Dion et al. where 15 kidneys were randomly assigned to the cold storage group and the contralateral kidney was assigned to the hypothermic machine perfusion sought to examine whether machine perfusion has an effect on vascular...
Diagnosing the Decades-Long Rise in the Deceased Donor Kidney Discard Rate in the United States
Stewart et al. wanted to examine why there has been a steady increase in the percent of discarded kidneys from 5.1% in 1988 to 19.2% by 2009 where it leveled off until 2015. They looked at a variety of factors to see if the increase in discards could be attributed...