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Everyone going the extra mile – ECU Health transplants kidney flown commercially on LifePort Kidney Transporter
Adapted from ECU health's article Ruth McCorkle spent years traveling around the world during retirement on solo trips and trips with friends. In September 2023, her traveling was put on pause when unexpectedly learned she had serious kidney issue. Within days, she...
Ex vivo machine perfusion of extended-criteria donor livers: a Bayesian network meta-analysis
A meta-analysis published in International Journal of Surgery compared hypothermic oxygenated perfusion (HOPE) vs normothermic machine perfusion (NMP) for extended criteria donor (ECD) livers, HOPE vs dual hypothermic machine perfusion (D-HOPE), and whether to pump...
Matched pair analysis of the effect of longer hypothermic machine perfusion time on kidney transplant outcomes
This single-center study published in World Journal of Transplantation looked at deceased donor kidney transplant pairs occurring at University of Saskatchewan between 2012 and 2021. Both donor kidneys were placed on LifePort Kidney Transporter prior to transplant....
“Hope and Hurdles” in Liver Machine Perfusion: A Review and Future Directions of Machine Perfusion in Liver Transplantation
This comprehensive review by O’Kane et al. explores the evolving landscape of liver machine perfusion, highlighting promising advancements and remaining challenges. Since Guarrera et al. published the first ex-situ HMP clinical series in 2010, HMP has been found to...
The Evolution of Kidney Graft Preservation Through the Years
In this review, the authors provide a comprehensive overview of the evolution of kidney graft preservation methods, detailing the transition from traditional SCS to more advanced technologies, such as HMP and HOPE. HMP has demonstrated advantages in reducing DGF and...
Impact of Warm Ischemia Time on DCD Kidney Transplant Outcomes
This single-center retrospective review by Alghannam et al. looked at the impact of functional warm ischemic time (fWIT) in controlled DCD donors by comparing donor/recipient characteristics and outcomes between high fWIT (>60min), low fWIT (<60min), and DBD...
Cold Ischemia Time and Delayed Function in Kidney Transplantation: A Paired Kidney Analysis
This retrospective cohort study by Husain et al. analyzed US registry data. Investigators identified kidney pairs from the same donor where there was a notable difference in CIT between the kidneys. The results showed that: Out of 25,831 kidney pairs, 71% had...
Use of Machine Perfusion to Increase the Number of Expanded Criteria Deceased Donor Kidney Transplants: A Pharmacoeconomic Analysis
A recent pharmacoeconomic study from Brazil by Tedesco Silva Junior et al. sought to evaluate the cost-effectiveness and budgetary impact of incorporating hypothermic machine perfusion (HMP) for preserving extended criteria donor (ECD) kidneys. They found that...
Overcoming the longest cold ischemia time seen in Korea using HMP in deceased donor kidney transplantation
Kim et al. reported on a deceased donor kidney transplant case that had the longest reported cold ischemic time (CIT) in Korea which was facilitated by using hypothermic machine perfusion (HMP). A 54 year old male marginal deceased donor (Korean Kidney Donor Profile...
Local12—Machine perfusion leading to more organ viability for liver transplants
LifePort Liver Transporter has not been cleared or approved by FDA, and the safety and effectiveness of the LifePort Liver Transporter has not been established. LifePort Liver Transporter is not available for sale within the United States. Organ Recovery Systems (ORS)...
Portable hypothermic oxygenated machine perfusion for organ preservation in liver transplantation (PILOT): A randomized, open-label, clinical trial
LifePort Liver Transporter has not been cleared or approved by FDA, and the safety and effectiveness of the LifePort Liver Transporter has not been established. LifePort Liver Transporter is not available for sale within the United States. Panayotova et al. published...
Brief Bubble and Intermittent Surface Oxygenation Is a Simple and Effective Alternative for Membrane Oxygenation During Hypothermic Machine Perfusion in Kidneys
A study by Darius et al. sought to evaluate the use of direct bubble and intermittent surface oxygenation during continuous HMP as an alternative to using a membrane oxygenator. They evaluated the renal flow, resistance and concentration of pO2 in the perfusate as...
Intermittent Surface Oxygenation Results in Similar Mitochondrial Protection and Maintenance of Aerobic Metabolism as Compared to Continuous Oxygenation during Kidney HMP
A study by Darius et al. evaluated the metabolic effect of a short interruption of surface oxygenation compared to continuous surface and membrane oxygenation in a pig kidney model. They looked at ATP levels as well as the pO2 measures, renal flow and resistance, and...
First clinical kidney transplantation series using brief bubble and direct surface oxygenation as alternative for membrane oxygenation during HMP
A study by Darius et al. reported on the first 5 cases of using the method of bubble and intermittent surface oxygenation during HMP in human renal transplantation. This case study provided information on 3 DCD donors of which 5 of the 6 kidneys were allocated to...
LifePort Liver Transporter by Organ Recovery Systems Achieves 100 Perfused Livers in Continued Access Study
LifePort Liver Transporter has not been cleared or approved by FDA, and the safety and effectiveness of the LifePort Liver Transporter has not been established. LifePort Liver Transporter is not available for sale within the United States. Organ Recovery Systems (ORS)...
Decreased incidence of DGF in a high-DGF population
A recent paper published in Brazil by Tedesco-Silva et al. sought to determine the impact of hypothermic machine perfusion (HMP) on kidneys with a high incidence of delayed graft function (DGF). They performed a paired kidney analysis of 80 kidney pairs and evaluated...
LifePort Liver Transporter by Organ Recovery Systems Wins Fast Company’s 2023 Innovation by Design Award in the ‘Health’ Category
Organ Recovery Systems (ORS) is honored to announce that its LifePort Liver Transporter was selected as the winner in the ‘Health’ category in Fast Company’s Innovation by Design Awards for 2023. The Innovation by Design Awards, which can be found in the September...
The first use of hypothermic machine perfusion in Korea to recover a procured kidney graft and prevent prolonged cold ischemic time: a case report
Shin et al. reported on the first deceased donor kidney transplant case using hypothermic machine perfusion (HMP) on Jeju Island, Korea. A single deceased donor with several hours of marginal oxygen saturation had both kidneys assigned to Jeju Island. Due to...