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Renal Resistance Trend During HMP Is More Predictive of Postoperative Outcome Than Biopsy Score
Bissolati et al. sought evaluate the prognostic role of renal resistance (RR) valued during hypothermic machine perfusion (HMP) on postoperative outcome. They analyzed 65 kidneys that were preserved using HMP from DCD and ECD donors. They found: Kidneys that reached...
The Impact of Hypothermic Pulsatile Machine Perfusion Versus Static Cold Storage on Delayed Graft Function
A retrospective paired kidney study by de Sandes-Freitas et al. sought to determine whether hypothermic machine perfusion (HMP) was beneficial in their unique situation where the kidney is placed on HMP after a long period of static cold storage (SCS). They compared...
Hypothermic Machine Perfusion in Liver Transplantation
A recent review article by Karangwa et al. looked at the current and ongoing evidence for hypothermic machine perfusion (HMP) in liver transplantation. They presented the following results of studies: HMP had significantly better post-operative liver function compared...
A Retrospective Propensity Score Matched Analysis Reveals Superiority of Hypothermic Machine Perfusion over Static Cold Storage in Deceased Donor Kidney Transplantation
Gasteiger et al. performed a retrospective analysis of all kidney transplant recipients between August 2015 and December of 2019 performed at the Medical University of Innsbrook. The study included 347 patients of which 124 of the recipient organs had been preserved...
Pulsatile Perfusion Reduces the Risk of Delayed Graft Function in Deceased Donor Kidney Transplants, Irrespective of Donor Type and Cold Ischemic Time
In a 2013 publication, Gill et.al. sought to examine two things: the patterns of utilization of hypothermic machine perfusion (HMP) as a function of cold ischemic time (CIT) and donor type as well as the impact of HMP on the risk of DGF by CIT and donor type. They...
LifePort Mobile App Clinical FAQ References
Cited References 1 Gill et al; Pulsatile perfusion reduces the risk of delayed graft function in deceased donor kidney transplants, irrespective of donor type and cold ischemia time; Transplantation; 2014.2 Bissolati et al; Renal Resistance Trend During Hypothermic...
To Pump or Not to Pump: A Comparison of Machine Perfusion vs Cold Storage for Deceased Donor Kidney Transplantation
Cannon et al. performed a retrospective analysis of the UNOS database from January 2005 to March of 2011, which included 52,052 kidney recipients. They found that there was: Significantly less DGF in both Propensity matched cohort (21.1% MP vs 29.1% SCS) Paired kidney...
Machine Perfusion versus Cold Storage for Preservation of Kidneys from Expanded Criteria Donors after Brain Death
In an article based on the expanded criteria donor (ECD) subset from the machine perfusion trial, Treckmann et al. analyzed 91 donors where one kidney was assigned to the machine perfusion (MP) group and the contralateral kidney was preserved by static cold storage...
Machine Perfusion Decreases Delayed Graft Function in Donor Grafts With High Kidney Donor Profile Index
In the era of KDPI, Montenovo et al. sought to assess the impact of the use of machine perfusion (MP) on the incidence of delayed graft function (DGF) in the different groups of kidney grafts classified by kidney donor profile index (KDPI). They used the UNOS database...
Improved post-transplant resistive indices and long-term function in DCD kidneys preserved by HMP
A single-center paired kidney study by Dion et al. where 15 kidneys were randomly assigned to the cold storage group and the contralateral kidney was assigned to the hypothermic machine perfusion sought to examine whether machine perfusion has an effect on vascular...
Diagnosing the Decades-Long Rise in the Deceased Donor Kidney Discard Rate in the United States
Stewart et al. wanted to examine why there has been a steady increase in the percent of discarded kidneys from 5.1% in 1988 to 19.2% by 2009 where it leveled off until 2015. They looked at a variety of factors to see if the increase in discards could be attributed...
HMP provides safe and reliable preservation of “orphan” livers
In a study of 31 adult ECD livers that were declined by the originating UNOS region, Guarrera et al sought to determine whether the use of HMP could reduce the incidence and clinical impact of classic preservation injuries. They compared these livers to a historic...
Machine Perfusion or Cold Storage in Deceased-Donor Kidney Transplantation
In 2009, Moers et al. published the largest ever randomized controlled trial comparing paired kidneys that were either subjected to hypothermic machine perfusion (HMP) or cold storage (CS). This study included 336 kidney pairs that were randomized to either the HMP...
1-Year Kidney Transplant Outcomes Superior with Pressure-Driven Machine Perfusion
A team from Warsaw Medical University, Poland, has reported results from a prospective, randomized, trial comparing Organ Recovery System’s LifePort®, a pressure driven (PD) device, with Waters Medical Systems’ RM3, a flow driven (FD) device.1 This is the first time...
Hypothermic Machine Perfusion — Cost-Effective Compared with Cold Storage
An abstract presented at the American Transplant Congress (ATC) in May 2013 by Dr. Victoria Gomez et al. evaluated the budgetary impact and incremental cost-effectiveness of hypothermic machine perfusion compared with static cold storage.1 Kidneys transplanted from...
US Study Shows Significantly Lower Rates of DGF and Better Graft Survival in Machine Perfused Compared with Cold Stored Kidneys (N=52,052)
A study by Cannon et al. published in the April 2013 issue of the Journal of the American College of Surgeons, demonstrated a statistically significant reduction in delayed graft function (DGF) in kidneys preserved with machine perfusion compared with static cold...
LifePort Offers Gentle, Pressure-Controlled Pulsatile Perfusion
Pumping a donor kidney with the LifePort Kidney Transporter preserves and protects the organ in a number of ways before it is transplanted. One of the most important features is the use of gentle, pulsatile pressure waves to ensure that cold preservation solution is...